James Rowe’s men travel to the Racecourse Ground on the back of a three-game winless run, including two straight defeats to Bromley and Halifax.
Wrexham, meanwhile, have won both of their previous two matches against Halifax and Woking 4-0, moving them up to sixth in the table.
The Blues bolstered their attacking options with the signing of striker Danny Rowe from Bradford City on Thursday.
Here is Liam Norcliffe’s predicted Chesterfield starting line-up...
1. Ross Fitzsimons - GK
He has started the last 12 consecutive games and there's no reason to think he won't do again. Photo: Pete Norton
2. Jeff King - RB
His assist at the weekend took him to seven for the season, as well as his seven goals. Photo: Tina Jenner
3. Ash Palmer - CB
Made his first start on Saturday since signing from Stockport County and put in a solid display. Photo: Tina Jenner
4. Jamie Grimes - CB
He has still played every minute of every game this season. Photo: Tina Jenner