The Spireites will face the third-placed League Two side on Saturday, November 5.
It will be the first meeting between the two teams in more than five years, the last occasion being a 3-1 home win for the Cobblers in February 2017, which was a League One game.
Northampton were 3-0 up after 48 minutes thanks to a brace from John-Joe O’Toole and a strike from former Spireite Marc Richards. David Faupala pulled a goal back but Chesterfield fell to defeat.
But the Spireites have happier memories from the last time they were at home in this fixture, winning 3-1 in September 2016 to end Northampton’s 31-game unbeaten league run.
Let’s take a look at who started for the Blues the last time the two teams clashed...
1. Lloyd Allinson
The stopper only made a small number of appearances before moving to FC United of Manchester. He is now at Pontefract Collieries in the Northern Premier League. Photo: Pete Norton
2. Sadiq El Fitouri
The defender's time at the Spireites was very brief, making just two appearances, before he was fined for going AWOL. He reportedly signed for a club in his native Libya. After that, nobody really knows what happened to him. It's a mystery. Photo: Pete Norton
3. Tom Anderson
The centre-back was on loan from Burnley at the time. He has gone on to make more than 100 appearances for Doncaster Rovers. Photo: Howard Roe/ahpix.com
4. Ian Evatt
The fan favourite made more than 200 appearances across two spells for the club. He is currently the manager of League One Bolton Wanderers. Photo: Pete Norton